A Jadson hat-trick helped Corinthians into the Copa Libertadores last 16, while Penarol were denied a place in the knockout stage.
Jadson netted three times to see Corinthians to a 7-2 thrashing of Deportivo Lara in Venezuela on Thursday.
The 34-year-old produced a classy left-footed finish to open the scoring before doubling the lead from the penalty spot just after the half-hour mark.
Jose Miguel Reyes brought Deportivo back into the contest on the stroke of half-time, firing into the roof of the net from an angle.
But Jadson completed his hat-trick shortly after the break with another brilliant finish, side-footing a half-volley into the corner.
Sidcley made it 4-1 for Corinthians before Jesus Hernandez scored Deportivo's second, but the visitors sealed their win through Angel Romero and Junior Dutra – the latter coming off the bench to score in the 100th and 101st minutes.
Com três gols de Jadson, dois de Júnior Dutra, um de Romero e outro de Sidcley, Corinthians goleia e se classifica para as oitavas de final da Conmebol Libertadores!#VaiCorinthians pic.twitter.com/fFlQA6PjYk — Corinthians (@Corinthians) May 18, 2018
With the result, Corinthians moved three points clear atop Group 7, securing a spot in the knockout stage.
Millonarios and Independiente drew 1-1 in Bogota, with the latter in second and well-placed to advance.
In Group 3, Penarol finished third despite claiming a 2-0 win at home to The Strongest.
The Uruguayan giants needed a win and for Atletico Tucuman to lose at group winners Libertad, but the Argentine outfit held on for a 0-0 draw with 10 men.